Fractional flow reserve (FFR) is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine the likelihood that the stenosis impedes oxygen delivery to the heart muscle (myocardial ischemia).
FFR is a novel and potentially clinically useful mathematical model for estimation of stenotic coronary artery atherosclerosis. Reliability/collaborative (easily reproducible) measurement between competing laboratories in measuring this essential metric remains muddled in a proprietary race to claim cardiac mathematics dedicated to risk in ischemic cardiac disease. Proprietary claims of cardiac mathematics have not been previously argued in patent law. The race towards ownership of proprietary claims in defining ischemic disease remains elusive. Legal precedents abound stating mathematics should not be burdened by patent law.
Fractional flow reserve is defined as the pressure after (distal to) a stenosis relative to the pressure before the stenosis. The result is an absolute number; an FFR of 0.80 means that a given stenosis causes a 20% drop in blood pressure. In other words, FFR expresses the maximal flow down a vessel in the presence of a stenosis compared to the maximal flow in the hypothetical absence of the stenosis.
The RXi system with the ultra-thin ACIST Navvus® Rapid Exchange FFR MicroCatheter gives you the freedom to quickly and easily assess FFR using your wire of choice.